Cargando…

Conformational changes in the catalytically inactive nucleotide-binding site of CFTR

A central step in the gating of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is the association of its two cytosolic nucleotide-binding domains (NBDs) into a head-to-tail dimer, with two nucleotides bound at the interface. Channel opening and closing, respectively,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Csanády, László, Mihályi, Csaba, Szollosi, Andras, Töröcsik, Beáta, Vergani, Paola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2013
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691448/ https://www.ncbi.nlm.nih.gov/pubmed/23752332 http://dx.doi.org/10.1085/jgp.201210954

Ejemplares similares

Obligate coupling of CFTR pore opening to tight nucleotide-binding domain dimerization
por: Mihályi, Csaba, et al.
Publicado: (2016)

Simple binding of protein kinase A prior to phosphorylation allows CFTR anion channels to be opened by nucleotides
por: Mihályi, Csaba, et al.
Publicado: (2020)

Involvement of F1296 and N1303 of CFTR in induced-fit conformational change in response to ATP binding at NBD2
por: Szollosi, Andras, et al.
Publicado: (2010)

Mutant cycles at CFTR’s non-canonical ATP-binding site support little interface separation during gating
por: Szollosi, Andras, et al.
Publicado: (2011)

Asymmetry of movements in CFTR's two ATP sites during pore opening serves their distinct functions
por: Sorum, Ben, et al.
Publicado: (2017)

Cystic fibrosis drug ivacaftor stimulates CFTR channels at picomolar concentrations
por: Csanády, László, et al.
Publicado: (2019)

Structure–activity analysis of a CFTR channel potentiator: Distinct molecular parts underlie dual gating effects
por: Csanády, László, et al.
Publicado: (2014)

Catalyst-like modulation of transition states for CFTR channel opening and closing: New stimulation strategy exploits nonequilibrium gating
por: Csanády, László, et al.
Publicado: (2014)

Four Ca(2+) Ions Activate TRPM2 Channels by Binding in Deep Crevices near the Pore but Intracellularly of the Gate
por: Csanády, László, et al.
Publicado: (2009)

Functional Roles of Nonconserved Structural Segments in CFTR's NH(2)-terminal Nucleotide Binding Domain
por: Csanády, László, et al.
Publicado: (2005)

Thermodynamics of CFTR Channel Gating: A Spreading Conformational Change Initiates an Irreversible Gating Cycle
por: Csanády, László, et al.
Publicado: (2006)

Prolonged Nonhydrolytic Interaction of Nucleotide with CFTR's NH(2)-terminal Nucleotide Binding Domain and its Role in Channel Gating
por: Basso, Claudia, et al.
Publicado: (2003)

CFTR gating: Invisible transitions made visible
por: Csanády, László
Publicado: (2017)

The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity
por: Iordanov, Iordan, et al.
Publicado: (2016)

Selective profiling of N- and C-terminal nucleotide-binding sites in a TRPM2 channel
por: Tóth, Balázs, et al.
Publicado: (2020)

Blue flash sheds light on the roles of individual phosphoserines in CFTR channel activation
por: Csanády, László
Publicado: (2023)

Cftr Channel Gating: Incremental Progress in Irreversible Steps
por: Csanády, László, et al.
Publicado: (1999)

Optimization of CFTR gating through the evolution of its extracellular loops
por: Simon, Márton A., et al.
Publicado: (2023)

Enzyme activity and selectivity filter stability of ancient TRPM2 channels were simultaneously lost in early vertebrates
por: Iordanov, Iordan, et al.
Publicado: (2019)

Estimating the true stability of the prehydrolytic outward-facing state in an ABC protein
por: Simon, Márton A, et al.
Publicado: (2023)

Reconstituted IMPDH polymers accommodate both catalytically active and inactive conformations
por: Anthony, Sajitha A., et al.
Publicado: (2017)

Dual Effects of Adp and Adenylylimidodiphosphate on Cftr Channel Kinetics Show Binding to Two Different Nucleotide Binding Sites
por: Weinreich, Frank, et al.
Publicado: (1999)

Structure of a TRPM2 channel in complex with Ca(2+) explains unique gating regulation
por: Zhang, Zhe, et al.
Publicado: (2018)

Allosteric Coupling between the Intracellular Coupling Helix 4 and Regulatory Sites of the First Nucleotide-binding Domain of CFTR
por: Dawson, Jennifer E., et al.
Publicado: (2013)

CFTR Gating II: Effects of Nucleotide Binding on the Stability of Open States
por: Bompadre, Silvia G., et al.
Publicado: (2005)

CFTR: the nucleotide binding folds regulate the accessibility and stability of the activated state
Publicado: (1996)

Absence of Ca(2+)-Induced Mitochondrial Permeability Transition but Presence of Bongkrekate-Sensitive Nucleotide Exchange in C. crangon and P. serratus
por: Konrad, Csaba, et al.
Publicado: (2012)

Catalytically inactive telomerase in oncogenesis
por: Tergaonkar, Vinay
Publicado: (2015)

Modeling the Conformational Changes Underlying Channel Opening in CFTR
por: Rahman, Kazi S., et al.
Publicado: (2013)

Alanine mutation of the catalytic sites of Pantothenate Synthetase causes distinct conformational changes in the ATP binding region
por: Pandey, Bharati, et al.
Publicado: (2018)

Nucleotide binding is the critical regulator of ABCG2 conformational transitions
por: Gyöngy, Zsuzsanna, et al.
Publicado: (2023)

Degenerate ABC composite site is stably glued together by trapped ATP
por: Csanády, László
Publicado: (2010)

On the Mechanism of MgATP-dependent Gating of CFTR Cl(−) Channels
por: Vergani, Paola, et al.
Publicado: (2003)

Tweaking the catalytic efficiency of the CFTR ion channel
por: McCarty, Nael A.
Publicado: (2023)

Erlotinib binds both inactive and active conformations of the EGFR tyrosine kinase domain
por: Park, Jin H., et al.
Publicado: (2012)

Antagonistic Regulation of Native Ca(2+)- and ATP-sensitive Cation Channels in Brain Capillaries by Nucleotides and Decavanadate
por: Csanády, László, et al.
Publicado: (2004)

Human ABCB1 with an ABCB11-like degenerate nucleotide binding site maintains transport activity by avoiding nucleotide occlusion
por: Goda, Katalin, et al.
Publicado: (2020)

Structure of Transmembrane Helix 8 and Possible Membrane Defects in CFTR
por: Corradi, Valentina, et al.
Publicado: (2018)

Severed Molecules Functionally Define the Boundaries of the Cystic Fibrosis Transmembrane Conductance Regulator's Nh(2)-Terminal Nucleotide Binding Domain
por: Chan, Kim W., et al.
Publicado: (2000)

A single active catalytic site is sufficient to promote transport in P-glycoprotein
por: Bársony, Orsolya, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_fvor7fp1oc12bvi6109o8b1hcn