The spindle checkpoint, APC/C(Cdc20), and APC/C(Cdh1) play distinct roles in connecting mitosis to S phase

DNA replication depends on a preceding licensing event by Cdt1 and Cdc6. In animal cells, relicensing after S phase but before mitosis is prevented by the Cdt1 inhibitor geminin and mitotic cyclin activity. Here, we show that geminin, like cyclin B1 and securin, is a bona fide target of the spindle...

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Detalles Bibliográficos
Autores principales: Clijsters, Linda, Ogink, Janneke, Wolthuis, Rob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691463/
https://www.ncbi.nlm.nih.gov/pubmed/23775192
http://dx.doi.org/10.1083/jcb.201211019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691463/
https://www.ncbi.nlm.nih.gov/pubmed/23775192
http://dx.doi.org/10.1083/jcb.201211019

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