Cargando…

Abnormal Ca(2+) homeostasis, atrial arrhythmogenesis, and sinus node dysfunction in murine hearts modeling RyR2 modification

Ryanodine receptor type 2 (RyR2) mutations are implicated in catecholaminergic polymorphic ventricular tachycardia (CPVT) thought to result from altered myocyte Ca(2+) homeostasis reflecting inappropriate “leakiness” of RyR2-Ca(2+) release channels arising from increases in their basal activity, alt...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yanmin, Matthews, Gareth D. K., Lei, Ming, Huang, Christopher L.-H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2013
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691467/ https://www.ncbi.nlm.nih.gov/pubmed/23805105 http://dx.doi.org/10.3389/fphys.2013.00150

Ejemplares similares

Acute atrial arrhythmogenicity and altered Ca(2+) homeostasis in murine RyR2-P2328S hearts
por: Zhang, Yanmin, et al.
Publicado: (2011)

MicroRNA-1 and -133 Increase Arrhythmogenesis in Heart Failure by Dissociating Phosphatase Activity from RyR2 Complex
por: Belevych, Andriy E., et al.
Publicado: (2011)

Identification of RyR2-PBmice and the effects of transposon insertional mutagenesis of the RyR2 gene on cardiac function in mice
por: Wang, Qianqian, et al.
Publicado: (2019)

Identification of ATP-Binding Regions in the RyR1 Ca(2+) Release Channel
por: Popova, Olga B., et al.
Publicado: (2012)

Both RyRs and TPCs are required for NAADP-induced intracellular Ca(2+) release
por: Gerasimenko, Julia V., et al.
Publicado: (2015)

Pharmacological changes in cellular Ca(2+) homeostasis parallel initiation of atrial arrhythmogenesis in murine langendorff-perfused hearts
por: Zhang, Yanmin, et al.
Publicado: (2009)

On the Adjacency Matrix of RyR2 Cluster Structures
por: Walker, Mark A., et al.
Publicado: (2015)

RyR2 and Calcium Release in Heart Failure
por: Benitah, Jean-Pierre, et al.
Publicado: (2021)

Simvastatin activates single skeletal RyR1 channels but exerts more complex regulation of the cardiac RyR2 isoform
por: Venturi, Elisa, et al.
Publicado: (2018)

RyR2 Modulates a Ca(2+)-Activated K(+) Current in Mouse Cardiac Myocytes
por: Mu, Yong-hui, et al.
Publicado: (2014)

ER stress increases expression of intracellular calcium channel RyR1 to modify Ca(2+) homeostasis in pancreatic beta cells
por: Zhang, Irina X., et al.
Publicado: (2023)

Flecainide exerts paradoxical effects on sodium currents and atrial arrhythmia in murine RyR2-P2328S hearts
por: Salvage, S C, et al.
Publicado: (2015)

Structure of RyR1 in native membranes
por: Chen, Wenbo, et al.
Publicado: (2020)

Structural insights into Ca(2+)-activated long-range allosteric channel gating of RyR1
por: Wei, Risheng, et al.
Publicado: (2016)

Age attenuates the T‐type Ca(V)3.2‐RyR axis in vascular smooth muscle
por: Fan, Gang, et al.
Publicado: (2020)

Acute RyR1 Ca(2+) leak enhances NADH-linked mitochondrial respiratory capacity
por: Zanou, Nadège, et al.
Publicado: (2021)

Reconciling depressed Ca(2+) sparks occurrence with enhanced RyR2 activity in failing mice cardiomyocytes
por: Ruiz-Hurtado, Gema, et al.
Publicado: (2015)

Ca(2+)-dependent calmodulin binding to cardiac ryanodine receptor (RyR2) calmodulin-binding domains
por: Brohus, Malene, et al.
Publicado: (2019)

Exercise Training Stabilizes RyR2-Dependent Ca(2+) Release in Post-infarction Heart Failure
por: Danielsen, Tore Kristian, et al.
Publicado: (2021)

Epac activation, altered calcium homeostasis and ventricular arrhythmogenesis in the murine heart
por: Hothi, Sandeep S., et al.
Publicado: (2008)

Ca(2+)-Dependent Phosphorylation of RyR2 Can Uncouple Channel Gating from Direct Cytosolic Ca(2+) Regulation
por: Carter, Simon, et al.
Publicado: (2011)

ß-Adrenergic Stimulation Increases RyR2 Activity via Intracellular Ca(2+) and Mg(2+) Regulation
por: Li, Jiao, et al.
Publicado: (2013)

Molecular, Subcellular, and Arrhythmogenic Mechanisms in Genetic RyR2 Disease
por: Fowler, Ewan Douglas, et al.
Publicado: (2022)

How does flecainide impact RyR2 channel function?
por: Salvage, Samantha C., et al.
Publicado: (2022)

Review of RyR1 pathway and associated pathomechanisms
por: Witherspoon, Jessica W., et al.
Publicado: (2016)

Dantrolene-Induced Inhibition of Skeletal L-Type Ca(2+) Current Requires RyR1 Expression
por: Bannister, R. A.
Publicado: (2013)

Examination of the Effects of Heterogeneous Organization of RyR Clusters, Myofibrils and Mitochondria on Ca(2+) Release Patterns in Cardiomyocytes
por: Rajagopal, Vijay, et al.
Publicado: (2015)

Expression of voltage-gated Ca(2+) channels, Insp(3)Rs, and RyRs in the immature mouse ovary
por: Bahena-Alvarez, Daniel, et al.
Publicado: (2022)

Luminal Ca(2+)–regulated Mg(2+) Inhibition of Skeletal RyRs Reconstituted as Isolated Channels or Coupled Clusters
por: Laver, Derek R., et al.
Publicado: (2004)

Voltage-Dependent Modulation of Cardiac Ryanodine Receptors (RyR2) by Protamine
por: Diaz-Sylvester, Paula L., et al.
Publicado: (2009)

Zinc controls RyR2 activity during excitation-contraction coupling
por: Stewart, Alan J, et al.
Publicado: (2015)

RyR2 QQ2958 Genotype and Risk of Malignant Ventricular Arrhythmias
por: Galati, Francesca, et al.
Publicado: (2016)

Synergistic FRET assays for drug discovery targeting RyR2 channels
por: Rebbeck, RobynT., et al.
Publicado: (2022)

The biophysical properties of TRIC-A and TRIC-B and their interactions with RyR2
por: Hu, Jianshu, et al.
Publicado: (2023)

Bidirectional TRP/L Type Ca(2+) Channel/RyR/BK(Ca) Molecular and Functional Signaloplex in Vascular Smooth Muscles
por: Dryn, Dariia O., et al.
Publicado: (2023)

Regulation of Ca(2+) Sparks by Ca(2+) and Mg(2+) in Mammalian and Amphibian Muscle. An RyR Isoform-specific Role in Excitation–Contraction Coupling?
por: Zhou, Jingsong, et al.
Publicado: (2004)

Measurement of RyR permeability reveals a role of calsequestrin in termination of SR Ca(2+) release in skeletal muscle
por: Sztretye, Monika, et al.
Publicado: (2011)

Roles of IP(3)R and RyR Ca(2+) Channels in Endoplasmic Reticulum Stress and β-Cell Death
por: Luciani, Dan S., et al.
Publicado: (2009)

Senolytics prevent caveolar Ca(V)3.2‐RyR axis malfunction in old vascular smooth muscle
por: Lin, Jie, et al.
Publicado: (2023)

Physiological consequences of the P2328S mutation in the ryanodine receptor (RyR2) gene in genetically modified murine hearts
por: Goddard, C A, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_988bjbi412v47qpg0lpngdv06g