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Acetyl-CoA the Key Factor for Survival or Death of Cholinergic Neurons in Course of Neurodegenerative Diseases

Glucose-derived pyruvate is a principal source of acetyl-CoA in all brain cells, through pyruvate dehydogenase complex (PDHC) reaction. Cholinergic neurons like neurons of other transmitter systems and glial cells, utilize acetyl-CoA for energy production in mitochondria and diverse synthetic pathwa...

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Detalles Bibliográficos
Autores principales: Szutowicz, Andrzej, Bielarczyk, Hanna, Jankowska-Kulawy, Agnieszka, Pawełczyk, Tadeusz, Ronowska, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691476/
https://www.ncbi.nlm.nih.gov/pubmed/23677775
http://dx.doi.org/10.1007/s11064-013-1060-x