Evolutionary dynamics of cancer in response to targeted combination therapy

In solid tumors, targeted treatments can lead to dramatic regressions, but responses are often short-lived because resistant cancer cells arise. The major strategy proposed for overcoming resistance is combination therapy. We present a mathematical model describing the evolutionary dynamics of lesio...

Descripción completa

Detalles Bibliográficos
Autores principales: Bozic, Ivana, Reiter, Johannes G, Allen, Benjamin, Antal, Tibor, Chatterjee, Krishnendu, Shah, Preya, Moon, Yo Sup, Yaqubie, Amin, Kelly, Nicole, Le, Dung T, Lipson, Evan J, Chapman, Paul B, Diaz, Luis A, Vogelstein, Bert, Nowak, Martin A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Genomics and Evolutionary Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691570/
https://www.ncbi.nlm.nih.gov/pubmed/23805382
http://dx.doi.org/10.7554/eLife.00747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691570/
https://www.ncbi.nlm.nih.gov/pubmed/23805382
http://dx.doi.org/10.7554/eLife.00747

Ejemplares similares