Aldose reductase from Schistosoma japonicum: crystallization and structure-based inhibitor screening for discovering antischistosomal lead compounds

BACKGROUND: Schistosomiasis is a neglected tropical disease with high morbidity and mortality in the world. Currently, the treatment of this disease depends almost exclusively on praziquantel (PZQ); however, the emergence of drug resistance to PZQ in schistosomes makes the development of novel drugs...

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Detalles Bibliográficos
Autores principales: Liu, Jian, Dyer, David H, Cheng, Jingdong, Wang, Jipeng, Wang, Shuqi, Yang, Zhong, Wang, Xiaoning, Hu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691639/
https://www.ncbi.nlm.nih.gov/pubmed/23734964
http://dx.doi.org/10.1186/1756-3305-6-162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691639/
https://www.ncbi.nlm.nih.gov/pubmed/23734964
http://dx.doi.org/10.1186/1756-3305-6-162

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