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Comparison of the effectiveness of antibody and cell-mediated immunity against inhaled and instilled influenza virus challenge

BACKGROUND: To evaluate immunity against influenza, mouse challenge studies are typically performed by intranasal instillation of a virus suspension to anesthetized animals. This results in an unnatural environment in the lower respiratory tract during infection, and therefore there is some concern...

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Detalles Bibliográficos
Autores principales:	Rivers, Katie, Bowen, Larry E, Gao, Jin, Yang, Kevin, Trombley, John E, Bohannon, J Kyle, Eichelberger, Maryna C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691648/ https://www.ncbi.nlm.nih.gov/pubmed/23777453 http://dx.doi.org/10.1186/1743-422X-10-198

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