Utilizing protein structure to identify non-random somatic mutations

BACKGROUND: Human cancer is caused by the accumulation of somatic mutations in tumor suppressors and oncogenes within the genome. In the case of oncogenes, recent theory suggests that there are only a few key “driver” mutations responsible for tumorigenesis. As there have been significant pharmacolo...

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Detalles Bibliográficos
Autores principales: Ryslik, Gregory A, Cheng, Yuwei, Cheung, Kei-Hoi, Modis, Yorgo, Zhao, Hongyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691676/
https://www.ncbi.nlm.nih.gov/pubmed/23758891
http://dx.doi.org/10.1186/1471-2105-14-190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691676/
https://www.ncbi.nlm.nih.gov/pubmed/23758891
http://dx.doi.org/10.1186/1471-2105-14-190

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