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High level of susceptibility to human TRIM5α conferred by HIV-2 capsid sequences

BACKGROUND: HIV-2, which was transmitted to humans from a distant primate species (sooty mangabey), differs remarkably from HIV-1 in its infectivity, transmissibility and pathogenicity. We have tested the possibility that a greater susceptibility of HIV-2 capsid (CA) to the human restriction factor...

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Detalles Bibliográficos
Autores principales: Takeuchi, Junko S, Perche, Benjamin, Migraine, Julie, Mercier-Delarue, Séverine, Ponscarme, Diane, Simon, François, Clavel, François, Labrosse, Béatrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691696/
https://www.ncbi.nlm.nih.gov/pubmed/23647667
http://dx.doi.org/10.1186/1742-4690-10-50