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The transition state structure for coupled binding and folding of disordered protein domains

Intrinsically disordered proteins are abundant in the eukaryotic proteome, and they are implicated in a range of different diseases. However, there is a paucity of experimental data on molecular details of the coupled binding and folding of such proteins. Two interacting and relatively well studied...

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Detalles Bibliográficos
Autores principales: Dogan, Jakob, Mu, Xin, Engström, Åke, Jemth, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691887/
https://www.ncbi.nlm.nih.gov/pubmed/23799450
http://dx.doi.org/10.1038/srep02076