Disease-associated mutations in CNGB3 promote cytotoxicity in photoreceptor-derived cells

PURPOSE: To determine if achromatopsia associated F525N and T383fsX mutations in the CNGB3 subunit of cone photoreceptor cyclic nucleotide-gated (CNG) channels increases susceptibility to cell death in photoreceptor-derived cells. METHODS: Photoreceptor-derived 661W cells were transfected with cDNA...

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Detalles Bibliográficos
Autores principales: Liu, Chunming, Sherpa, Tshering, Varnum, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692405/
https://www.ncbi.nlm.nih.gov/pubmed/23805033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692405/
https://www.ncbi.nlm.nih.gov/pubmed/23805033

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