A Lack of Premature Termination Codon Read-Through Efficacy of PTC124 (Ataluren) in a Diverse Array of Reporter Assays

The drug molecule PTC124 (Ataluren) has been described as a read-through agent, capable of suppressing premature termination codons (PTCs) and restoring functional protein production from genes disrupted by nonsense mutations. Following the discovery of PTC124 there was some controversy regarding it...

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Detalles Bibliográficos
Autores principales: McElroy, Stuart P., Nomura, Toshifumi, Torrie, Leah S., Warbrick, Emma, Gartner, Ulrike, Wood, Gavin, McLean, W. H. Irwin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692445/
https://www.ncbi.nlm.nih.gov/pubmed/23824517
http://dx.doi.org/10.1371/journal.pbio.1001593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692445/
https://www.ncbi.nlm.nih.gov/pubmed/23824517
http://dx.doi.org/10.1371/journal.pbio.1001593

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