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Germinal Center B-Cells Resist Transformation by Kras Independently of Tumor Suppressor Arf
Activating mutations in Ras (N- and K-) are the most common point mutations found in patients with multiple myeloma (MM) and are associated with poor clinical outcome. We sought to directly examine the role of Ras activation in MM pathogenesis and used two different tissue-specific Cre recombinase m...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692489/ https://www.ncbi.nlm.nih.gov/pubmed/23825691 http://dx.doi.org/10.1371/journal.pone.0067941 |