Introducing a Rigid Loop Structure from Deer into Mouse Prion Protein Increases Its Propensity for Misfolding In Vitro

Prion diseases are fatal neurodegenerative disorders characterized by misfolding of the cellular prion protein (PrP(c)) into the disease-associated isoform (PrP(Sc)) that has increased β-sheet content and partial resistance to proteolytic digestion. Prion diseases from different mammalian species ha...

Descripción completa

Detalles Bibliográficos
Autores principales: Kyle, Leah M., John, Theodore R., Schätzl, Hermann M., Lewis, Randolph V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692500/
https://www.ncbi.nlm.nih.gov/pubmed/23825561
http://dx.doi.org/10.1371/journal.pone.0066715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692500/
https://www.ncbi.nlm.nih.gov/pubmed/23825561
http://dx.doi.org/10.1371/journal.pone.0066715

Ejemplares similares