Lkb1 Loss Promotes Tumor Progression of BRAF(V600E)-Induced Lung Adenomas

Aberrant activation of MAP kinase signaling pathway and loss of tumor suppressor LKB1 have been implicated in lung cancer development and progression. Although oncogenic KRAS mutations are frequent, BRAF mutations (BRAF(V600E)) are found in 3% of human non-small cell lung cancers. Contrary to KRAS m...

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Detalles Bibliográficos
Autores principales: González-Sánchez, Elena, Martín-Caballero, Juan, Flores, Juana María, Hernández-Losa, Javier, Cortés, Javier, Mares, Roso, Barbacid, Mariano, Recio, Juan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692542/
https://www.ncbi.nlm.nih.gov/pubmed/23825589
http://dx.doi.org/10.1371/journal.pone.0066933

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692542/
https://www.ncbi.nlm.nih.gov/pubmed/23825589
http://dx.doi.org/10.1371/journal.pone.0066933

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