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Lkb1 Loss Promotes Tumor Progression of BRAF(V600E)-Induced Lung Adenomas
Aberrant activation of MAP kinase signaling pathway and loss of tumor suppressor LKB1 have been implicated in lung cancer development and progression. Although oncogenic KRAS mutations are frequent, BRAF mutations (BRAF(V600E)) are found in 3% of human non-small cell lung cancers. Contrary to KRAS m...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692542/ https://www.ncbi.nlm.nih.gov/pubmed/23825589 http://dx.doi.org/10.1371/journal.pone.0066933 |