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A Robust Method to Analyze Copy Number Alterations of Less than 100 kb in Single Cells Using Oligonucleotide Array CGH

Comprehensive genome wide analyses of single cells became increasingly important in cancer research, but remain to be a technically challenging task. Here, we provide a protocol for array comparative genomic hybridization (aCGH) of single cells. The protocol is based on an established adapter-linker...

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Detalles Bibliográficos
Autores principales: Möhlendick, Birte, Bartenhagen, Christoph, Behrens, Bianca, Honisch, Ellen, Raba, Katharina, Knoefel, Wolfram T., Stoecklein, Nikolas H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692546/
https://www.ncbi.nlm.nih.gov/pubmed/23825608
http://dx.doi.org/10.1371/journal.pone.0067031