Contrasting effects of Deadend1 (Dnd1) gain and loss of function mutations on allelic inheritance, testicular cancer, and intestinal polyposis

BACKGROUND: Certain mutations in the Deadend1 (Dnd1) gene are the most potent modifiers of testicular germ cell tumor (TGCT) susceptibility in mice and rats. In the 129 family of mice, the Dnd1(Ter) mutation significantly increases occurrence of TGCT-affected males. To test the hypothesis that he Dn...

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Detalles Bibliográficos
Autores principales: Zechel, Jennifer L, Doerner, Stephanie K, Lager, Angela, Tesar, Paul J, Heaney, Jason D, Nadeau, Joseph H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693958/
https://www.ncbi.nlm.nih.gov/pubmed/23773267
http://dx.doi.org/10.1186/1471-2156-14-54

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693958/
https://www.ncbi.nlm.nih.gov/pubmed/23773267
http://dx.doi.org/10.1186/1471-2156-14-54

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