Germline Mutations in Mtap Cooperate with Myc to Accelerate Tumorigenesis in Mice

OBJECTIVE: The gene encoding the methionine salvage pathway methylthioadenosine phosphorylase (MTAP) is a tumor suppressor gene that is frequently inactivated in a wide variety of human cancers. In this study, we have examined if heterozygosity for a null mutation in Mtap (Mtap(lacZ)) could accelera...

Descripción completa

Detalles Bibliográficos
Autores principales: Kadariya, Yuwaraj, Tang, Baiqing, Wang, Liqun, Al-Saleem, Tahseen, Hayakawa, Kyoko, Slifker, Michael J., Kruger, Warren D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694069/
https://www.ncbi.nlm.nih.gov/pubmed/23840755
http://dx.doi.org/10.1371/journal.pone.0067635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694069/
https://www.ncbi.nlm.nih.gov/pubmed/23840755
http://dx.doi.org/10.1371/journal.pone.0067635

Ejemplares similares