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Germline Mutations in Mtap Cooperate with Myc to Accelerate Tumorigenesis in Mice
OBJECTIVE: The gene encoding the methionine salvage pathway methylthioadenosine phosphorylase (MTAP) is a tumor suppressor gene that is frequently inactivated in a wide variety of human cancers. In this study, we have examined if heterozygosity for a null mutation in Mtap (Mtap(lacZ)) could accelera...
Autores principales: | Kadariya, Yuwaraj, Tang, Baiqing, Wang, Liqun, Al-Saleem, Tahseen, Hayakawa, Kyoko, Slifker, Michael J., Kruger, Warren D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694069/ https://www.ncbi.nlm.nih.gov/pubmed/23840755 http://dx.doi.org/10.1371/journal.pone.0067635 |
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