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Stochastic Tunneling of Two Mutations in a Population of Cancer Cells

Cancer initiation, progression, and the emergence of drug resistance are driven by specific genetic and/or epigenetic alterations such as point mutations, structural alterations, DNA methylation and histone modification changes. These alterations may confer advantageous, deleterious or neutral effec...

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Detalles Bibliográficos
Autores principales: Haeno, Hiroshi, Maruvka, Yosef E., Iwasa, Yoh, Michor, Franziska
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694076/
https://www.ncbi.nlm.nih.gov/pubmed/23840359
http://dx.doi.org/10.1371/journal.pone.0065724