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Modeling the Insulin-Like Growth Factor System in Articular Cartilage

IGF signaling is involved in cell proliferation, differentiation and apoptosis in a wide range of tissues, both normal and diseased, and so IGF-IR has been the focus of intense interest as a promising drug target. In this computational study on cartilage, we focus on two questions: (i) what are the...

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Detalles Bibliográficos
Autores principales: Zhang, Lihai, Smith, David W., Gardiner, Bruce S., Grodzinsky, Alan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694163/
https://www.ncbi.nlm.nih.gov/pubmed/23840540
http://dx.doi.org/10.1371/journal.pone.0066870