Rate-Limiting Steps in Yeast Protein Translation

Deep sequencing now provides detailed snapshots of ribosome occupancy on mRNAs. We leverage these data to parameterize a computational model of translation, keeping track of every ribosome, tRNA, and mRNA molecule in a yeast cell. We determine the parameter regimes in which fast initiation or high c...

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Detalles Bibliográficos
Autores principales: Shah, Premal, Ding, Yang, Niemczyk, Malwina, Kudla, Grzegorz, Plotkin, Joshua B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
Materias:
Theory
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694300/
https://www.ncbi.nlm.nih.gov/pubmed/23791185
http://dx.doi.org/10.1016/j.cell.2013.05.049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694300/
https://www.ncbi.nlm.nih.gov/pubmed/23791185
http://dx.doi.org/10.1016/j.cell.2013.05.049

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