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A Meta-Analysis Identifies New Loci Associated with Body Mass index in Individuals of African Ancestry

Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry, and followed...

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Autores principales: Monda, Keri L., Chen, Gary K., Taylor, Kira C., Palmer, Cameron, Edwards, Todd L., Lange, Leslie A., Ng, Maggie C.Y., Adeyemo, Adebowale A., Allison, Matthew A., Bielak, Lawrence F., Chen, Guanji, Graff, Mariaelisa, Irvin, Marguerite R., Rhie, Suhn K., Li, Guo, Liu, Yongmei, Liu, Youfang, Lu, Yingchang, Nalls, Michael A., Sun, Yan V., Wojczynski, Mary K., Yanek, Lisa R., Aldrich, Melinda C., Ademola, Adeyinka, Amos, Christopher I., Bandera, Elisa V., Bock, Cathryn H., Britton, Angela, Broeckel, Ulrich, Cai, Quiyin, Caporaso, Neil E., Carlson, Chris, Carpten, John, Casey, Graham, Chen, Wei-Min, Chen, Fang, Chen, Yii-Der I., Chiang, Charleston W.K., Coetzee, Gerhard A., Demerath, Ellen, Deming-Halverson, Sandra L., Driver, Ryan W., Dubbert, Patricia, Feitosa, Mary F., Freedman, Barry I., Gillanders, Elizabeth M., Gottesman, Omri, Guo, Xiuqing, Haritunians, Talin, Harris, Tamara, Harris, Curtis C., Hennis, Anselm JM, Hernandez, Dena G., McNeill, Lorna H., Howard, Timothy D., Howard, Barbara V., Howard, Virginia J., Johnson, Karen C., Kang, Sun J., Keating, Brendan J., Kolb, Suzanne, Kuller, Lewis H., Kutlar, Abdullah, Langefeld, Carl D., Lettre, Guillaume, Lohman, Kurt, Lotay, Vaneet, Lyon, Helen, Manson, JoAnn E., Maixner, William, Meng, Yan A., Monroe, Kristine R., Morhason-Bello, Imran, Murphy, Adam B., Mychaleckyj, Josyf C., Nadukuru, Rajiv, Nathanson, Katherine L., Nayak, Uma, N’Diaye, Amidou, Nemesure, Barbara, Wu, Suh-Yuh, Leske, M. Cristina, Neslund-Dudas, Christine, Neuhouser, Marian, Nyante, Sarah, Ochs-Balcom, Heather, Ogunniyi, Adesola, Ogundiran, Temidayo O., Ojengbede, Oladosu, Olopade, Olufunmilayo I., Palmer, Julie R., Ruiz-Narvaez, Edward A., Palmer, Nicholette D., Press, Michael F., Rampersaud, Evandine, Rasmussen-Torvik, Laura J., Rodriguez-Gil, Jorge L., Salako, Babatunde, Schadt, Eric E., Schwartz, Ann G., Shriner, Daniel A., Siscovick, David, Smith, Shad B., Wassertheil-Smoller, Sylvia, Speliotes, Elizabeth K., Spitz, Margaret R., Sucheston, Lara, Taylor, Herman, Tayo, Bamidele O., Tucker, Margaret A., Van Den Berg, David J., Velez Edwards, Digna R., Wang, Zhaoming, Wiencke, John K., Winkler, Thomas W., Witte, John S., Wrensch, Margaret, Wu, Xifeng, Yang, James J., Levin, Albert M., Young, Taylor R., Zakai, Neil A., Cushman, Mary, Zanetti, Krista A., Zhao, Jing Hua, Zhao, Wei, Zheng, Yonglan, Zhou, Jie, Ziegler, Regina G., Zmuda, Joseph M., Fernandes, Jyotika K., Gilkeson, Gary S., Kamen, Diane L., Hunt, Kelly J., Spruill, Ida J., Ambrosone, Christine B., Ambs, Stefan, Arnett, Donna K., Atwood, Larry, Becker, Diane M., Berndt, Sonja I., Bernstein, Leslie, Blot, William J., Borecki, Ingrid B., Bottinger, Erwin P., Bowden, Donald W., Burke, Gregory, Chanock, Stephen J., Cooper, Richard S., Ding, Jingzhong, Duggan, David, Evans, Michele K., Fox, Caroline, Garvey, W. Timothy, Bradfield, Jonathan P., Hakonarson, Hakon, Grant, Struan F.A., Hsing, Ann, Chu, Lisa, Hu, Jennifer J., Huo, Dezheng, Ingles, Sue A., John, Esther M., Jordan, Joanne M., Kabagambe, Edmond K., Kardia, Sharon L.R., Kittles, Rick A., Goodman, Phyllis J., Klein, Eric A., Kolonel, Laurence N., Le Marchand, Loic, Liu, Simin, McKnight, Barbara, Millikan, Robert C., Mosley, Thomas H., Padhukasahasram, Badri, Williams, L. Keoki, Patel, Sanjay R., Peters, Ulrike, Pettaway, Curtis A., Peyser, Patricia A., Psaty, Bruce M., Redline, Susan, Rotimi, Charles N., Rybicki, Benjamin A., Sale, Michèle M., Schreiner, Pamela J., Signorello, Lisa B., Singleton, Andrew B., Stanford, Janet L., Strom, Sara S., Thun, Michael J., Vitolins, Mara, Zheng, Wei, Moore, Jason H., Williams, Scott M., Zhu, Xiaofeng, Zonderman, Alan B., Kooperberg, Charles, Papanicolaou, George, Henderson, Brian E., Reiner, Alex P., Hirschhorn, Joel N., Loos, Ruth JF, North, Kari E., Haiman, Christopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694490/
https://www.ncbi.nlm.nih.gov/pubmed/23583978
http://dx.doi.org/10.1038/ng.2608