Functional evolution of scorpion venom peptides with an inhibitor cystine knot fold

The ICK (inhibitor cystine knot) defines a large superfamily of polypeptides with high structural stability and functional diversity. Here, we describe a new scorpion venom-derived K(+) channel toxin (named λ-MeuKTx-1) with an ICK fold through gene cloning, chemical synthesis, nuclear magnetic reson...

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Detalles Bibliográficos
Autores principales: Gao, Bin, Harvey, Peta J., Craik, David J., Ronjat, Michel, De Waard, Michel, Zhu, Shunyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2013
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694633/
https://www.ncbi.nlm.nih.gov/pubmed/23721518
http://dx.doi.org/10.1042/BSR20130052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694633/
https://www.ncbi.nlm.nih.gov/pubmed/23721518
http://dx.doi.org/10.1042/BSR20130052

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