Ubiquitin conjugation triggers misfolded protein sequestration into quality control foci when Hsp70 chaperone levels are limiting

Ubiquitin accumulation in amyloid plaques is a pathological marker observed in the vast majority of neurodegenerative diseases, yet ubiquitin function in these inclusions is controversial. It has been suggested that ubiquitylated proteins are directed to inclusion bodies under stress conditions, whe...

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Detalles Bibliográficos
Autores principales: Shiber, Ayala, Breuer, William, Brandeis, Michael, Ravid, Tommer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694792/
https://www.ncbi.nlm.nih.gov/pubmed/23637465
http://dx.doi.org/10.1091/mbc.E13-01-0010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694792/
https://www.ncbi.nlm.nih.gov/pubmed/23637465
http://dx.doi.org/10.1091/mbc.E13-01-0010

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