Saccharomyces cerevisiae DNA Ligase IV Supports Imprecise End Joining Independently of Its Catalytic Activity

DNA ligase IV (Dnl4 in budding yeast) is a specialized ligase used in non-homologous end joining (NHEJ) of DNA double-strand breaks (DSBs). Although point and truncation mutations arise in the human ligase IV syndrome, the roles of Dnl4 in DSB repair have mainly been examined using gene deletions. H...

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Detalles Bibliográficos
Autores principales: Chiruvella, Kishore K., Liang, Zhuobin, Birkeland, Shanda R., Basrur, Venkatesha, Wilson, Thomas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694833/
https://www.ncbi.nlm.nih.gov/pubmed/23825968
http://dx.doi.org/10.1371/journal.pgen.1003599

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694833/
https://www.ncbi.nlm.nih.gov/pubmed/23825968
http://dx.doi.org/10.1371/journal.pgen.1003599

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