Latent Effects of Hsp90 Mutants Revealed at Reduced Expression Levels

In natural systems, selection acts on both protein sequence and expression level, but it is unclear how selection integrates over these two dimensions. We recently developed the EMPIRIC approach to systematically determine the fitness effects of all possible point mutants for important regions of es...

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Detalles Bibliográficos
Autores principales: Jiang, Li, Mishra, Parul, Hietpas, Ryan T., Zeldovich, Konstantin B., Bolon, Daniel N. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694843/
https://www.ncbi.nlm.nih.gov/pubmed/23825969
http://dx.doi.org/10.1371/journal.pgen.1003600

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694843/
https://www.ncbi.nlm.nih.gov/pubmed/23825969
http://dx.doi.org/10.1371/journal.pgen.1003600

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