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Latent Effects of Hsp90 Mutants Revealed at Reduced Expression Levels
In natural systems, selection acts on both protein sequence and expression level, but it is unclear how selection integrates over these two dimensions. We recently developed the EMPIRIC approach to systematically determine the fitness effects of all possible point mutants for important regions of es...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694843/ https://www.ncbi.nlm.nih.gov/pubmed/23825969 http://dx.doi.org/10.1371/journal.pgen.1003600 |