Critical Significance of the Region between Helix 1 and 2 for Efficient Dominant-Negative Inhibition by Conversion-Incompetent Prion Protein

Prion diseases are fatal infectious neurodegenerative disorders in man and animals associated with the accumulation of the pathogenic isoform PrP(Sc) of the host-encoded prion protein (PrP(c)). A profound conformational change of PrP(c) underlies formation of PrP(Sc) and prion propagation involves c...

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Detalles Bibliográficos
Autores principales: Taguchi, Yuzuru, Mistica, Arla M. A., Kitamoto, Tetsuyuki, Schätzl, Hermann M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694865/
https://www.ncbi.nlm.nih.gov/pubmed/23825952
http://dx.doi.org/10.1371/journal.ppat.1003466

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694865/
https://www.ncbi.nlm.nih.gov/pubmed/23825952
http://dx.doi.org/10.1371/journal.ppat.1003466

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