MDM2 Inhibits Axin-Induced p53 Activation Independently of its E3 Ligase Activity

MDM2 plays a crucial role in negatively regulating the functions of tumor suppressor p53. Here we show that MDM2 can inhibit Axin-stimulated p53-dependent apoptosis by suppressing p53 phosphorylation at Ser 46 and apoptosis-related p53 transactivational activity. Interestingly, the ubiquitin E3 liga...

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Detalles Bibliográficos
Autores principales: He, Ying, Lian, Guili, Lin, Shuyong, Ye, Zhiyun, Li, Qinxi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694902/
https://www.ncbi.nlm.nih.gov/pubmed/23826318
http://dx.doi.org/10.1371/journal.pone.0067529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694902/
https://www.ncbi.nlm.nih.gov/pubmed/23826318
http://dx.doi.org/10.1371/journal.pone.0067529

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