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MDM2 Inhibits Axin-Induced p53 Activation Independently of its E3 Ligase Activity
MDM2 plays a crucial role in negatively regulating the functions of tumor suppressor p53. Here we show that MDM2 can inhibit Axin-stimulated p53-dependent apoptosis by suppressing p53 phosphorylation at Ser 46 and apoptosis-related p53 transactivational activity. Interestingly, the ubiquitin E3 liga...
Autores principales: | He, Ying, Lian, Guili, Lin, Shuyong, Ye, Zhiyun, Li, Qinxi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694902/ https://www.ncbi.nlm.nih.gov/pubmed/23826318 http://dx.doi.org/10.1371/journal.pone.0067529 |
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