Regulation of Constitutive GPR3 Signaling and Surface Localization by GRK2 and β-arrestin-2 Overexpression in HEK293 Cells

G protein-coupled receptor 3 (GPR3) is a constitutively active receptor that maintains high 3′-5′-cyclic adenosine monophosphate (cAMP) levels required for meiotic arrest in oocytes and CNS function. Ligand-activated G protein-coupled receptors (GPCRs) signal at the cell surface and are silenced by...

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Detalles Bibliográficos
Autores principales: Lowther, Katie M., Uliasz, Tracy F., Götz, Konrad R., Nikolaev, Viacheslav O., Mehlmann, Lisa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694969/
https://www.ncbi.nlm.nih.gov/pubmed/23826079
http://dx.doi.org/10.1371/journal.pone.0065365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694969/
https://www.ncbi.nlm.nih.gov/pubmed/23826079
http://dx.doi.org/10.1371/journal.pone.0065365

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