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The tRNA-modifying function of MnmE is controlled by post-hydrolysis steps of its GTPase cycle

MnmE is a homodimeric multi-domain GTPase involved in tRNA modification. This protein differs from Ras-like GTPases in its low affinity for guanine nucleotides and mechanism of activation, which occurs by a cis, nucleotide- and potassium-dependent dimerization of its G-domains. Moreover, MnmE requir...

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Detalles Bibliográficos
Autores principales: Prado, Silvia, Villarroya, Magda, Medina, Milagros, Armengod, M.-Eugenia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695501/
https://www.ncbi.nlm.nih.gov/pubmed/23630314
http://dx.doi.org/10.1093/nar/gkt320