Small molecule induced reactivation of mutant p53 in cancer cells

The p53 cancer mutant Y220C is an excellent paradigm for rescuing the function of conformationally unstable p53 mutants because it has a unique surface crevice that can be targeted by small-molecule stabilizers. Here, we have identified a compound, PK7088, which is active in vitro: PK7088 bound to t...

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Detalles Bibliográficos
Autores principales: Liu, Xiangrui, Wilcken, Rainer, Joerger, Andreas C., Chuckowree, Irina S., Amin, Jahangir, Spencer, John, Fersht, Alan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695503/
https://www.ncbi.nlm.nih.gov/pubmed/23630318
http://dx.doi.org/10.1093/nar/gkt305

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695503/
https://www.ncbi.nlm.nih.gov/pubmed/23630318
http://dx.doi.org/10.1093/nar/gkt305

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