Megakaryocytic leukemia 1 (MKL1) ties the epigenetic machinery to hypoxia-induced transactivation of endothelin-1

Increased synthesis of endothelin-1 (ET-1) by human vascular endothelial cells (HVECs) in response to hypoxia underscores persistent vasoconstriction observed in patients with pulmonary hypertension. The molecular mechanism whereby hypoxia stimulates ET-1 gene transcription is not well understood. H...

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Detalles Bibliográficos
Autores principales: Yang, Yuyu, Chen, Dewei, Yuan, Zhibin, Fang, Fei, Cheng, Xian, Xia, Jun, Fang, Mingming, Xu, Yong, Gao, Yuqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695508/
https://www.ncbi.nlm.nih.gov/pubmed/23625963
http://dx.doi.org/10.1093/nar/gkt311

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695508/
https://www.ncbi.nlm.nih.gov/pubmed/23625963
http://dx.doi.org/10.1093/nar/gkt311

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