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Challenges in homology search: HMMER3 and convergent evolution of coiled-coil regions

Detection of protein homology via sequence similarity has important applications in biology, from protein structure and function prediction to reconstruction of phylogenies. Although current methods for aligning protein sequences are powerful, challenges remain, including problems with homologous ov...

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Detalles Bibliográficos
Autores principales: Mistry, Jaina, Finn, Robert D., Eddy, Sean R., Bateman, Alex, Punta, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695513/
https://www.ncbi.nlm.nih.gov/pubmed/23598997
http://dx.doi.org/10.1093/nar/gkt263