Microfluidic affinity and ChIP-seq analyses converge on a conserved FOXP2-binding motif in chimp and human, which enables the detection of evolutionarily novel targets

The transcription factor forkhead box P2 (FOXP2) is believed to be important in the evolution of human speech. A mutation in its DNA-binding domain causes severe speech impairment. Humans have acquired two coding changes relative to the conserved mammalian sequence. Despite intense interest in FOXP2...

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Detalles Bibliográficos
Autores principales: Nelson, Christopher S., Fuller, Chris K., Fordyce, Polly M., Greninger, Alexander L., Li, Hao, DeRisi, Joseph L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695516/
https://www.ncbi.nlm.nih.gov/pubmed/23625967
http://dx.doi.org/10.1093/nar/gkt259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695516/
https://www.ncbi.nlm.nih.gov/pubmed/23625967
http://dx.doi.org/10.1093/nar/gkt259

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