Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA–PK

DNA double-strand breaks (DSB) are considered as the most deleterious DNA lesions, and their repair is further complicated by increasing damage complexity. However, the molecular effects of clustered lesions are yet not fully understood. As the locally restricted phosphorylation of H2AX to form γH2A...

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Detalles Bibliográficos
Autores principales: Meyer, Barbara, Voss, Kay-Obbe, Tobias, Frank, Jakob, Burkhard, Durante, Marco, Taucher-Scholz, Gisela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695524/
https://www.ncbi.nlm.nih.gov/pubmed/23620287
http://dx.doi.org/10.1093/nar/gkt304

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695524/
https://www.ncbi.nlm.nih.gov/pubmed/23620287
http://dx.doi.org/10.1093/nar/gkt304

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