The Effect of SOD1 Mutation on Cellular Bioenergetic Profile and Viability in Response to Oxidative Stress and Influence of Mutation-Type

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the progressive degeneration of motor neurons. Substantial evidence implicates oxidative stress and mitochondrial dysfunction as early events in disease progression. Our aim was to ascertain whether mutation o...

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Detalles Bibliográficos
Autores principales: Richardson, Katie, Allen, Scott P., Mortiboys, Heather, Grierson, Andrew J., Wharton, Stephen B., Ince, Paul G., Shaw, Pamela J., Heath, Paul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695905/
https://www.ncbi.nlm.nih.gov/pubmed/23840839
http://dx.doi.org/10.1371/journal.pone.0068256

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695905/
https://www.ncbi.nlm.nih.gov/pubmed/23840839
http://dx.doi.org/10.1371/journal.pone.0068256

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