The Overexpression of Twinkle Helicase Ameliorates the Progression of Cardiac Fibrosis and Heart Failure in Pressure Overload Model in Mice

Myocardial mitochondrial DNA (mtDNA) copy number decreases in heart failure. In post-myocardial infarction mice, increasing mtDNA copy number by overexpressing mitochondrial transcription factor attenuates mtDNA deficiency and ameliorates pathological remodeling thereby markedly improving survival....

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Detalles Bibliográficos
Autores principales: Tanaka, Atsushi, Ide, Tomomi, Fujino, Takeo, Onitsuka, Ken, Ikeda, Masataka, Takehara, Takako, Hata, Yuko, Ylikallio, Emil, Tyynismaa, Henna, Suomalainen, Anu, Sunagawa, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695923/
https://www.ncbi.nlm.nih.gov/pubmed/23840758
http://dx.doi.org/10.1371/journal.pone.0067642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695923/
https://www.ncbi.nlm.nih.gov/pubmed/23840758
http://dx.doi.org/10.1371/journal.pone.0067642

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