Visualization of Cytolytic T Cell Differentiation and Granule Exocytosis with T Cells from Mice Expressing Active Fluorescent Granzyme B

To evaluate acquisition and activation of cytolytic functions during immune responses we generated knock in (KI) mice expressing Granzyme B (GZMB) as a fusion protein with red fluorescent tdTomato (GZMB-Tom). As for GZMB in wild type (WT) lymphocytes, GZMB-Tom was absent from naïve CD8 and CD4 T cel...

Descripción completa

Detalles Bibliográficos
Autores principales: Mouchacca, Pierre, Schmitt-Verhulst, Anne-Marie, Boyer, Claude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695958/
https://www.ncbi.nlm.nih.gov/pubmed/23840635
http://dx.doi.org/10.1371/journal.pone.0067239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695958/
https://www.ncbi.nlm.nih.gov/pubmed/23840635
http://dx.doi.org/10.1371/journal.pone.0067239

Ejemplares similares