Gene Transfer of Mutant Mouse Cholinesterase Provides High Lifetime Expression and Reduced Cocaine Responses with No Evident Toxicity

Gene transfer of a human cocaine hydrolase (hCocH) derived from butyrylcholinesterase (BChE) by 5 mutations (A199S/F227A/S287G/A328W/Y332G) has shown promise in animal studies for treatment of cocaine addiction. To predict the physiological fate and immunogenicity of this enzyme in humans, a compara...

Descripción completa

Detalles Bibliográficos
Autores principales: Geng, Liyi, Gao, Yang, Chen, Xiabin, Hou, Shurong, Zhan, Chang-Guo, Radic, Zoran, Parks, Robin J., Russell, Stephen J., Pham, Linh, Brimijoin, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696080/
https://www.ncbi.nlm.nih.gov/pubmed/23840704
http://dx.doi.org/10.1371/journal.pone.0067446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696080/
https://www.ncbi.nlm.nih.gov/pubmed/23840704
http://dx.doi.org/10.1371/journal.pone.0067446

Ejemplares similares