Bim Mediates the Elimination of Functionally Unfit Th1 Responders from the Memory Pool

Selective clonal deletion in the CD4(+) T cell compartment during the transition from effector to memory is accompanied by enhanced expression of the pro-apoptotic Bcl-2 family member Bim. Here, we show that Bim deficiency enables the survival of poorly functional Th1 responders that are normally el...

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Detalles Bibliográficos
Autores principales: Jay, David C., Mitchell, Diana M., Williams, Matthew A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696111/
https://www.ncbi.nlm.nih.gov/pubmed/23840678
http://dx.doi.org/10.1371/journal.pone.0067363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696111/
https://www.ncbi.nlm.nih.gov/pubmed/23840678
http://dx.doi.org/10.1371/journal.pone.0067363

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