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Bim Mediates the Elimination of Functionally Unfit Th1 Responders from the Memory Pool
Selective clonal deletion in the CD4(+) T cell compartment during the transition from effector to memory is accompanied by enhanced expression of the pro-apoptotic Bcl-2 family member Bim. Here, we show that Bim deficiency enables the survival of poorly functional Th1 responders that are normally el...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696111/ https://www.ncbi.nlm.nih.gov/pubmed/23840678 http://dx.doi.org/10.1371/journal.pone.0067363 |