On the Origin of Large Flexibility of P-glycoprotein in the Inward-facing State

P-glycoprotein (Pgp) is one of the most biomedically relevant transporters in the ATP binding cassette (ABC) superfamily due to its involvement in developing multidrug resistance in cancer cells. Employing molecular dynamics simulations and double electron-electron resonance spectroscopy, we have in...

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Detalles Bibliográficos
Autores principales: Wen, Po-Chao, Verhalen, Brandy, Wilkens, Stephan, Mchaourab, Hassane S., Tajkhorshid, Emad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696692/
https://www.ncbi.nlm.nih.gov/pubmed/23658020
http://dx.doi.org/10.1074/jbc.M113.450114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696692/
https://www.ncbi.nlm.nih.gov/pubmed/23658020
http://dx.doi.org/10.1074/jbc.M113.450114

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