Cargando…

Efficient Biodistribution and Gene Silencing in the Lung epithelium via Intravenous Liposomal Delivery of siRNA

RNA interference (RNAi) may provide a therapeutic solution to many pulmonary epithelium diseases. However, the main barrier to the clinical use of RNAi remains the lack of efficient delivery vectors. Research has mainly concentrated on the intranasal route of delivery of short interfering RNA (siRNA...

Descripción completa

Detalles Bibliográficos
Autores principales:	McCaskill, Jana, Singhania, Richa, Burgess, Melinda, Allavena, Rachel, Wu, Sherry, Blumenthal, Antje, McMillan, Nigel AJ
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696903/ https://www.ncbi.nlm.nih.gov/pubmed/23736774 http://dx.doi.org/10.1038/mtna.2013.22

Ejemplares similares

Effective Delivery of PEGylated siRNA-Containing Lipoplexes to Extraperitoneal Tumours following Intraperitoneal Administration
por: Singhania, Akul, et al.
Publicado: (2011)

RNA Interference for the Treatment of Papillomavirus Disease
por: Singhania, Richa, et al.
Publicado: (2012)

Effects of PEG anchors in PEGylated siRNA lipoplexes on in vitro gene-silencing effects and siRNA biodistribution in mice
por: Hattori, Yoshiyuki, et al.
Publicado: (2020)

Potent Inhibition of Hendra Virus Infection via RNA Interference and Poly I:C Immune Activation
por: McCaskill, Jana L., et al.
Publicado: (2013)

siRNA-containing liposomes modified with polyarginine effectively silence the targeted gene
por: Zhang, Chunling, et al.
Publicado: (2006)

Effects of sterol derivatives in cationic liposomes on biodistribution and gene-knockdown in the lungs of mice systemically injected with siRNA lipoplexes
por: Hattori, Yoshiyuki, et al.
Publicado: (2021)

Radiolabelling of Antigen and Liposomes for Vaccine Biodistribution Studies
por: Henriksen-Lacey, Malou, et al.
Publicado: (2010)

Preparation, pharmacokinetics and biodistribution of baicalin-loaded liposomes
por: Wei, Yumeng, et al.
Publicado: (2014)

Reconstructive and Oncoplastic Surgery for Giant Phyllodes Tumors: A Single Center’s Experience
por: Pitsinis, Vassilis, et al.
Publicado: (2017)

Pathways of cellular internalisation of liposomes delivered siRNA and effects on siRNA engagement with target mRNA and silencing in cancer cells
por: Alshehri, Abdullah, et al.
Publicado: (2018)

Liposomal siRNA Formulations for the Treatment of Herpes Simplex Virus-1: In Vitro Characterization of Physicochemical Properties and Activity, and In Vivo Biodistribution and Toxicity Studies
por: Jbara-Agbaria, Doaa, et al.
Publicado: (2022)

Silencing SOCS1 via Liposome-Packed siRNA Sustains TLR4-Ligand Adjuvant
por: Hildebrand, Dagmar, et al.
Publicado: (2019)

Dietary diallyl disulfide supplementation attenuates ethanol-mediated pulmonary vitamin D speciate depletion in C57Bl/6 mice
por: McCaskill, Michael L., et al.
Publicado: (2015)

Chronic Ethanol Exposure Effects on Vitamin D Levels Among Subjects with Alcohol Use Disorder
por: Ogunsakin, Olalekan, et al.
Publicado: (2016)

Publisher Correction: Pathways of cellular internalisation of liposomes delivered siRNA and effects on siRNA engagement with target mRNA and silencing in cancer cells
por: Alshehri, Abdullah, et al.
Publicado: (2018)

Biodistribution and Pharmacokinectics of Liposomes and Exosomes in a Mouse Model of Sepsis
por: Mirzaaghasi, Amin, et al.
Publicado: (2021)

Effective In Vivo Topical Delivery of siRNA and Gene Silencing in Intact Corneal Epithelium Using a Modified Cell-Penetrating Peptide
por: Schiroli, Davide, et al.
Publicado: (2019)

Receptor-targeted liposome-peptide-siRNA nanoparticles represent an efficient delivery system for MRTF silencing in conjunctival fibrosis
por: Yu-Wai-Man, Cynthia, et al.
Publicado: (2016)

Formulation, antileukemia mechanism, pharmacokinetics, and biodistribution of a novel liposomal emodin
por: Wang, Tiechuang, et al.
Publicado: (2012)

Flurbiprofen-Loaded Stealth Liposomes: Studies on the Development, Characterization, Pharmacokinetics, and Biodistribution
por: Begum, MY, et al.
Publicado: (2012)

Biodistribution of Liposome-Encapsulated Bacteriophages and Their Transcytosis During Oral Phage Therapy
por: Otero, Jennifer, et al.
Publicado: (2019)

The role of size in PEGylated liposomal doxorubicin biodistribution and anti‐tumour activity
por: Dadpour, Saba, et al.
Publicado: (2022)

Divergent Roles of RPA Homologs of the Model Archaeon Halobacterium salinarum in Survival of DNA Damage
por: Evans, Jessica J., et al.
Publicado: (2018)

Older Veterans EmpoweRed To Use Regular Exercise (OVERTURE) II: Design and methods of a randomized controlled trial among older veterans with chronic health conditions
por: McCaskill, Gina M., et al.
Publicado: (2019)

A SARS-CoV-2 targeted siRNA-nanoparticle therapy for COVID-19
por: Idris, Adi, et al.
Publicado: (2021)

Serum 25-Hydroxyvitamin D and Diet Mediates Vaso-Occlusive Related Hospitalizations in Sickle-Cell Disease Patients
por: McCaskill, Michael L., et al.
Publicado: (2018)

COVID-19, Social Justice, and Clinical Cancer Research
por: Doroshow, James H, et al.
Publicado: (2020)

ASSOCIATION OF RESTRICTED LIFE SPACE MOBILITY WITH COGNITIVE FUNCTION WITHIN OLDER BLACKS AND WHITES WITH DIABETES
por: Clay, Olivio J, et al.
Publicado: (2019)

Correlation between radioactivity and chemotherapeutics of the (111)In-VNB-liposome in pharmacokinetics and biodistribution in rats
por: Lee, Wen-Chuan, et al.
Publicado: (2012)

Development of novel lipidic particles for siRNA delivery that are highly effective after 12 months storage
por: Clarke, Daniel, et al.
Publicado: (2019)

Therapeutic siRNA silencing in inflammatory monocytes
por: Leuschner, Florian, et al.
Publicado: (2011)

Liposomal Delivery of miR-34b-5p Induced Cancer Cell Death in Thyroid Carcinoma
por: Maroof, Hamidreza, et al.
Publicado: (2018)

Addressing, amplifying and switching DNAzyme functions by electrochemically-triggered release of metal ions
por: Freage, Lina, et al.
Publicado: (2015)

Effective carrier-free gene-silencing activity of cholesterol-modified siRNAs
por: Salim, Lidya, et al.
Publicado: (2018)

Homeostatic capabilities of the choroid plexus epithelium in Alzheimer's disease
por: Johanson, Conrad, et al.
Publicado: (2004)

Prophylactic intranasal administration of lipid nanoparticle formulated siRNAs reduce SARS-CoV-2 and RSV lung infection
por: Supramaniam, Aroon, et al.
Publicado: (2023)

Plasma clearance, biodistribution and therapeutic properties of mitoxantrone encapsulated in conventional and sterically stabilized liposomes after intravenous administration in BDF1 mice.
por: Chang, C. W., et al.
Publicado: (1997)

Nanocarriers for delivery of siRNA as gene silencing mediator
por: Morales-Becerril, Aideé, et al.
Publicado: (2022)

Accuracy of the “traffic light” clinical decision rule for serious bacterial infections in young children with fever: a retrospective cohort study
por: De, Sukanya, et al.
Publicado: (2013)

Preparation, Pharmacokinetics, Biodistribution, Antitumor Efficacy and Safety of Lx2-32c-Containing Liposome
por: Wang, Hongbo, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_h91c5t0nkjc6kn0saqeihfe9c2