Global lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of acute brain injury

Brain contains a highly diversified complement of molecular species of a mitochondria-specific phospholipid, cardiolipin (CL), which - due to its polyunsaturation - can readily undergo oxygenation. Here, we used global lipidomics analysis in experimental traumatic brain injury (TBI) and showed that...

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Detalles Bibliográficos
Autores principales: Ji, Jing, Kline, Anthony E, Amoscato, Andrew, Arias, Alejandro S, Sparvero, Louis J, Tyurin, Vladimir A, Tyurina, Yulia Y, Fink, Bruno, Manole, Mioara D, Puccio, Ava M, Okonkwo, David O, Cheng, Jeffrey P, Alexander, Henry, Clark, Robert SB, Kochanek, Patrick M, Wipf, Peter, Kagan, Valerian E, Bayýr, Hülya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697869/
https://www.ncbi.nlm.nih.gov/pubmed/22922784
http://dx.doi.org/10.1038/nn.3195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697869/
https://www.ncbi.nlm.nih.gov/pubmed/22922784
http://dx.doi.org/10.1038/nn.3195

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