Low-dose temozolomide before dendritic-cell vaccination reduces (specifically) CD4(+)CD25(++)Foxp3(+) regulatory T-cells in advanced melanoma patients

BACKGROUND: In cancer immunotherapy, dendritic cells (DCs) play a fundamental role in the dialog between innate and adaptive immune response, but several immunosuppressive mechanisms remain to be overcome. For example, a high number of CD4(+)CD25(++)Foxp3(+) regulatory T-cells (Foxp3+Tregs) have bee...

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Detalles Bibliográficos
Autores principales: Ridolfi, Laura, Petrini, Massimiliano, Granato, Anna Maria, Gentilcore, Giusy, Simeone, Ester, Ascierto, Paolo Antonio, Pancisi, Elena, Ancarani, Valentina, Fiammenghi, Laura, Guidoboni, Massimo, de Rosa, Francesco, Valmorri, Linda, Scarpi, Emanuela, Nicoletti, Stefania Vittoria Luisa, Baravelli, Stefano, Riccobon, Angela, Ridolfi, Ruggero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698134/
https://www.ncbi.nlm.nih.gov/pubmed/23725550
http://dx.doi.org/10.1186/1479-5876-11-135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698134/
https://www.ncbi.nlm.nih.gov/pubmed/23725550
http://dx.doi.org/10.1186/1479-5876-11-135

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