The design of a new truncated and engineered alpha1-antitrypsin based on theoretical studies: an antiprotease therapeutics for pulmonary diseases

Alpha 1- antitrypsin (α1AT) a 54 kDa glycoprotein is a protease inhibitor. In the absence of α1AT, elastase released by lung macrophages, was not inhibited and lead to elastin breakdown and pulmonary problems such as emphysema or COPD. α1AT has three site of N-glycosylation and a characteristic reac...

Descripción completa

Detalles Bibliográficos
Autores principales: Pirooznia, Nazanin, Hasannia, Sadegh, Arab, Seyed Shahriar, Lotfi, Abbas Sahebghadam, Ghanei, Mostafa, Shali, Abbas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698207/
https://www.ncbi.nlm.nih.gov/pubmed/23705923
http://dx.doi.org/10.1186/1742-4682-10-36

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698207/
https://www.ncbi.nlm.nih.gov/pubmed/23705923
http://dx.doi.org/10.1186/1742-4682-10-36

Ejemplares similares